High numbers of PDCD1 (PD-1)-positive T cells and B2M mutations in microsatellite-unstable colorectal cancer
نویسندگان
چکیده
منابع مشابه
Regulatory T Cells in Colorectal Cancer
One of the essential protection mechanisms of immune system is Treg cells which play an important role in maintenance ofimmune homeostasis. However, they may also inhibit immune functions against tumor cells. It has been reported that Treg cellsare increased in patients suffering from different types of cancer. Increased number of Treg cells has been shown in tumor lymphnodes, peripheral blood,...
متن کاملSurvival in microsatellite-unstable colorectal cancer.
To the Editors: We read with interest Malesci et al’s article in the recent issue of Clinical Cancer Research (1). They showed that microsatellite instability (MSI) was a significant stagedependent predictor of survival in patients with colorectal cancer. Malesci et al. introduced our previous results and also showed that patients with transforming growth factor-h RII– mutated MSI cancer had be...
متن کاملDetection of Microsatellite Instability by High-Resolution Melting Analysis in Colorectal Cancer
Background: Colorectal cancer (CRC) is the third most common cancer worldwide. microsatellite instability (MSI) is a molecular marker of a deficient mismatch repair system and happens in almost 15% of CRCs. Because of a wide frequency of MSI+ CRC in Iran compared to other parts of the world, the importance of screening for this type of cancer is highlighted. Methods: The most common MSI detecti...
متن کاملBackground mutation frequency in microsatellite-unstable colorectal cancer.
Microsatellite instability (MSI) is observed in approximately 12% of colorectal cancers. Genes containing a mononucleotide microsatellite in the coding sequence are particularly prone to inactivation in MSI tumorigenesis, and much work has been conducted to identify genes with high repetitive tract mutation rates in these tumors. Much less attention has been paid to background mutation frequenc...
متن کاملMolecular genetics of microsatellite-unstable colorectal cancer for pathologists
BACKGROUND Microsatellite-unstable colorectal cancers (CRC) that are due to deficient DNA mismatch repair (dMMR) represent approximately 15% of all CRCs in the United States. These microsatellite-unstable CRCs represent a heterogenous group of diseases with distinct oncogenesis pathways. There are overlapping clinicopathologic features between some of these groups, but many important difference...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2017
ISSN: 2162-402X
DOI: 10.1080/2162402x.2017.1390640